Protective Effects of Alpha-Lipoic Acid on Glutamate-Induced Cytotoxicity in C6 Glioma Cells

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Protective effects of quinic acid derivatives on tetrahydropapaveroline-induced cell death in C6 glioma cells.

Protective effects of quinic acids from Aster scaber on tetrahydropapaveroline (THP)-induced cell toxicity were evaluated in rat C6 glioma cells. Among 4 quinic acid derivatives tested, (-) 4,5-dicaffeoyl quinic acid (QA3) exhibited the highest protective effect against THP-induced cell toxicity. C6 cells treated with THP exhibited the decrease in the survival rate and activities of glutathione...

متن کامل

Effects and mechanism of lipoic acid on beta-amyloid-intoxicated C6 glioma cells.

β-amyloid peptides (Aβs) can exert neurotoxic effects through induction of oxidative damage, whereas lipoic acid (LA), a powerful antioxidant, can alleviate oxidative damage. In this study, we explored the effect and mechanism of action of LA on beta-amyloid-intoxicated C6 glioma cells. Cells were randomly divided into three groups: control (vehicle), Aβ, and LA + Aβ. The LA + Aβ group was trea...

متن کامل

Protective effects of alpha-lipoic Acid on oleic Acid-induced acute lung injury in rats.

BACKGROUND Oxidative stress is believed to be an important factor in the pathogenesis of acute lung injury (ALI). AIMS The aim of this study was to investigate the possible protective role of alpha-lipoic acid (α-LA) on oleic acid (OA)-induced ALI in rats. STUDY DESIGN Animal experiment. METHODS A total of thirty-five rats were divided into five groups in the study. Group 1 served as a co...

متن کامل

Protective effects of alpha lipoic acid on radiation-induced salivary gland injury in rats

PURPOSE Radiation therapy is a treatment for patients with head and neck (HN) cancer. However, radiation exposure to the HN often induces salivary gland (SG) dysfunction. We investigated the effect of α-lipoic acid (ALA) on radiation-induced SG injury in rats. RESULTS ALA preserved acinoductal integrity and acinar cell secretary function following irradiation. These results are related to the...

متن کامل

Protective effects of alpha-lipoic acid and coenzyme Q10 on lipopolysaccharide-induced liver injury in rats

Lipopolysaccharide (LPS) is a major cell wall component of gram-negative bacteria known to stimulate the synthesis and secretion of several toxic metabolites, such as reactive oxygen species and cytokines. In this study, the protective effect of alpha-lipoic acid (ALA) and coenzyme Q10 (CoQ10) were evaluated in LPS-induced hepatic injury in rats. To this end, male adult Sprague Dawley rats were...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Biological and Pharmaceutical Bulletin

سال: 2019

ISSN: 0918-6158,1347-5215

DOI: 10.1248/bpb.b18-00603